Question by dslkfsdhf: Please! Important question about amphetamine abuse! Also, Focalin XR 30mg Overdose question?
I have had many issues with pill addiction in the past, stopped for 2 years but started again a couple months ago.
Since coming to university it started with 40mg of vyvanse a couple times a week to study but now it’s like week long binges of vyvanse, focalin, concerta, and some others, including methadone which is new for me, but ever since I snorted that I cannot stop thinking about it, it’s gotten to the point where I ask my dealer for it everyday and don’t even realize
Which is my first concern because when I was 14-16 I used to have problems with pills and alcohol and ruined a lot of things/relationships in my life, now I’m 18, failing all my classes because I haven’t been to class in the last month, spending my days just trying to find anyway possible to get high.
The thing I’m worried about is when I come down or am sober I get so depressed I cry for hours, have mental breakdowns/panic attacks, and seriously want to die.
I would never be one to say I have a problem but it’s really scaring me now, any advice or similar experiances?

Other question:
I took a 30mg of focalin xr 10 hours ago and snorted half of one and just took another 30mg like 2 hours ago maybe.
I am tweaking out harder than I ever have right now, like heart is racing, cold sweats, depressed, my whole body is shaking and I’m freezing cold.
What the does that mean?
I didn’t take enough to overdose right?
It’s only 75mg total of the focalin, I’ve taken probably 120mg of vyvanse before but not this much focalin so I don’t know what’s wrong with me.
Have you taken it?
How many mg til you OD?

Thanks everyone!
I don’t care if you judge me
Also! Important!
I am not prescribed anything!
I know it is illegal to buy/sell prescriptions but thats where I am at right now.

Forgot to add –
I’m 5’1, 100lbs
Haven’t eaten in almost 24 hours before popping/snorting that – except have a subway sub like an hour before doing all that last night.

Serious answers please, I know drugs aren’t cool obviously, I am an adult I did attend multiple years of health class throughout Middle School
Thanks!

Best answer:

Answer by eleusis211
You need help. I mean that in the least judgmental way possible. Get yourself checked into a detox if you feel you need it. The time you spend getting your life in order will be so worth it in the long run.

But there is no middle ground. If you can’t control your use you either need to stop using (everything) or try to keep living the way you are. If you don’t believe that, you can keep squandering years of your life like I did or decades like some of my friends did.

Answer by J Miller
The other poster is right, you need help. This is not going to stop if you don’t have help to stop it. You’re going to keep spiraling out of control worse and worse until you get help from someone else. It’s impossible to stop this on your own. If it wasn’t you would already have done it. Please do it now before it gets much much worse and you wake up 30 years old in jail with your life ruined. It happens all the time. It really sounds to me like you are in the early stages of a serious addiction. This is not a matter of using drugs. It’s addiction in it’s truest form.
Can your parents help you? Do you have insurance? If so please call your insurance company and see what kind of treatment they will pay for. You most likely need a lot more than a detox. Remember that quitting drugs is not that hard. It’s not starting again that is hard and most addicts relapse several times before they get clean. I’ve quit using more times than I can count and have been to several detoxes but I’ve relapsed every single time except for the last time I got into treatment seven years ago. But it took me ten years of using and trying to quit before I go there. You don’t want this going on ten years from now but chances are good that it will.

I highly recommend that you take a break from school and focus on your recovery. College is a lot of pressure and you don’t need that right now. You’re young and have plenty of time to do it later when you are in a better place.

One thing you can do today for support is to go to an NA meeting. They are all over and people there can help you go in the right direction. Check their website for times and locations. 12-step isn’t for everyone. It didn’t work for me but it does work for a lot of people and meeting are a great place for support.

Whatever you do please stop using the methadone. Methadone is a great medication for those who need it and are supervised by knowledgeable doctors but it can be an extremely dangerous drug when abused. When it comes to fatal drug overdoses methadone is one of the most common drugs to cause it. It’s not like other pills. It has a half life of over 24 hours so you will still have it in your system and can die from it long after the effects wear off. It slows down your respiration and it’s not uncommon that people die in their sleep because the body simply forgets to breathe because of the methadone and the natural slowed respiration when you sleep.
The dose of methadone that you can handle varies a lot from one person to another and even within one person from time to time. Your friend may be able to take 30mg while you take ten and die and what was okay for you last time may kill you this time. Mixing it with other drugs makes it even more dangerous especially if mixed with other opiates, alcohol or sedatives like benzos.
If you do take methadone please do not take it several days in a row. Because of the long half life methadone will build up in your system and the levels in your blood can become toxic even though you took the same dose every day.
It’s a very, very tricky drug and using it when you are not being treated by a knowledgeable doctor is playing with fire. It’s just not worth it. So many kids have died from messing with methadone.

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Question by Kevin7: has the drug GRN-29 improved autism symptoms in mice?

science daily news

Best answer:

Answer by Hαяνεγ βoi 416™
*GRN-529

Agent Reduces Autism-Like Behaviors in Mice: Boosts Sociability, Quells Repetitiveness

ScienceDaily (Apr. 25, 2012) — National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.

GRN-529 is a member of a class of agents that inhibit activity of a subtype of receptor protein on brain cells for the chemical messenger glutamate, which are being tested in patients with an autism-related syndrome. Although mouse brain findings often don’t translate to humans, the fact that these compounds are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers.

“Our findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms,” explained Jacqueline Crawley, Ph.D., of the NIH’s National Institute of Mental Health (NIMH). “Many cases of autism are caused by mutations in genes that control an ongoing process — the formation and maturation of synapses, the connections between neurons. If defects in these connections are not hard-wired, the core symptoms of autism may be treatable with medications.”

Crawley, Jill Silverman, Ph.D., and colleagues at NIMH and Pfizer Worldwide Research and Development, Groton, CT, report on their discovery April 25th, 2012 in the journal Science Translational Medicine.

“These new results in mice support NIMH-funded research in humans to create treatments for the core symptoms of autism,” said NIMH director Thomas R. Insel, M.D. “While autism has been often considered only as a disability in need of rehabilitation, we can now address autism as a disorder responding to biomedical treatments.”

Crawley’s team followed-up on clues from earlier findings hinting that inhibitors of the receptor, called mGluR5, might reduce ASD symptoms. This class of agents — compounds similar to GRN-529, used in the mouse study — are in clinical trials for patients with the most common form of inherited intellectual and developmental disabilities, Fragile X syndrome, about one third of whom also meet criteria for ASDs.

To test their hunch, the researchers examined effects of GRN-529 in a naturally occurring inbred strain of mice that normally display autism-relevant behaviors. Like children with ASDs, these BTBR mice interact and communicate relatively less with each other and engage in repetitive behaviors — most typically, spending an inordinate amount of time grooming themselves.

Crawley’s team found that BTBR mice injected with GRN-529 showed reduced levels of repetitive self-grooming and spent more time around — and sniffing nose-to-nose with — a strange mouse.

Moreover, GRN-529 almost completely stopped repetitive jumping in another strain of mice.

“These inbred strains of mice are similar, behaviorally, to individuals with autism for whom the responsible genetic factors are unknown, which accounts for about three fourths of people with the disorders,” noted Crawley. “Given the high costs — monetary and emotional — to families, schools, and health care systems, we are hopeful that this line of studies may help meet the need for medications that treat core symptoms.”
http://www.sciencedaily.com/releases/2012/04/120425143634.htm

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism (Abstract)
http://stm.sciencemag.org/content/4/131/131ra51

Question by puffer fish: Employment to large companies…drug tests?
I recently tried to apply to a large company to be an accountant, and they asked if I would be willing to do a hair folical test. I said yes, but never returned their phone call because I knew I would fail…I used cocaine and marijuana several months ago, and although it would be long gone in my urine or blood, I heard it stays in your hair folical for years…are most companies doing hair folical tests now?

Best answer:

Answer by 01001011
It’s hard to say “most” companies are doing hair follicle tests, since not all companies do drug tests prior to employment. But yes, of companies that do drug tests, the hair follicle test is becoming increasingly popular for its less invasive nature and wider window of detection than urine testing. Purportedly, in fact, “the Substance Abuse and Mental Health Services Administration has proposed new rules, in the final state of revision, that are likely to make hair the prime specimen for drug testing.”

However, supposedly the standard for testing is only about the first 1.5 inches of hair, which is more or less 90 days back depending on how fast your hair grows, even though how far they could test is only limited by the length of the hair. So it is possible you may have passed the drug test; the actualy time frame is fairly rough.

Answer by Tim
It is pretty much hit and miss.

I have some that do, most do not. It depends on the size of the company and the importance of the results to them.

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State senate forms committee to study drug addiction, treatment
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Question by Ratlinram: Americans that are prescribed drugs from doctors, how many actually fill and follow the prescription?
Yes, I am trying to get a creditable statistic.

Best answer:

Answer by vv
It’s hard to put a figure on this.
I should think that about 90% of prescriptions are filled when originally written and that (absent a financial problem) about 75% of those religiously follow directions as written and take all their medications.
There is an outfit on the West Coast that keeps these stats; IMS.

Answer by Kaytee Dee
“The National Institutes of Health (NIH) estimates that close to 20 percent of people (48 million) over the age of 12 in the U.S. have used prescription drugs for non-medical purposes.”

Just search for “prescription abuse statistics”. I’m sure you’ll get lots of hits.

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Stimulant-addicted patients can quit smoking without hindering treatment
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