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Bridging Medicaid's medical and behavioral care chasm
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Four running for probate/juvenile judge
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Roanoke teens' STD rate higher than state average
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Freeze the fat off!
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Karmanos Cancer Institute offers lung cancer screening program
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Elizabeth Furse, Washington County commissioner candidate, talks about Gain …
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Question by Kevin7: has the drug GRN-29 improved autism symptoms in mice?

science daily news

Best answer:

Answer by Hαяνεγ βoi 416™
*GRN-529

Agent Reduces Autism-Like Behaviors in Mice: Boosts Sociability, Quells Repetitiveness

ScienceDaily (Apr. 25, 2012) — National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.

GRN-529 is a member of a class of agents that inhibit activity of a subtype of receptor protein on brain cells for the chemical messenger glutamate, which are being tested in patients with an autism-related syndrome. Although mouse brain findings often don’t translate to humans, the fact that these compounds are already in clinical trials for an overlapping condition strengthens the case for relevance, according to the researchers.

“Our findings suggest a strategy for developing a single treatment that could target multiple diagnostic symptoms,” explained Jacqueline Crawley, Ph.D., of the NIH’s National Institute of Mental Health (NIMH). “Many cases of autism are caused by mutations in genes that control an ongoing process — the formation and maturation of synapses, the connections between neurons. If defects in these connections are not hard-wired, the core symptoms of autism may be treatable with medications.”

Crawley, Jill Silverman, Ph.D., and colleagues at NIMH and Pfizer Worldwide Research and Development, Groton, CT, report on their discovery April 25th, 2012 in the journal Science Translational Medicine.

“These new results in mice support NIMH-funded research in humans to create treatments for the core symptoms of autism,” said NIMH director Thomas R. Insel, M.D. “While autism has been often considered only as a disability in need of rehabilitation, we can now address autism as a disorder responding to biomedical treatments.”

Crawley’s team followed-up on clues from earlier findings hinting that inhibitors of the receptor, called mGluR5, might reduce ASD symptoms. This class of agents — compounds similar to GRN-529, used in the mouse study — are in clinical trials for patients with the most common form of inherited intellectual and developmental disabilities, Fragile X syndrome, about one third of whom also meet criteria for ASDs.

To test their hunch, the researchers examined effects of GRN-529 in a naturally occurring inbred strain of mice that normally display autism-relevant behaviors. Like children with ASDs, these BTBR mice interact and communicate relatively less with each other and engage in repetitive behaviors — most typically, spending an inordinate amount of time grooming themselves.

Crawley’s team found that BTBR mice injected with GRN-529 showed reduced levels of repetitive self-grooming and spent more time around — and sniffing nose-to-nose with — a strange mouse.

Moreover, GRN-529 almost completely stopped repetitive jumping in another strain of mice.

“These inbred strains of mice are similar, behaviorally, to individuals with autism for whom the responsible genetic factors are unknown, which accounts for about three fourths of people with the disorders,” noted Crawley. “Given the high costs — monetary and emotional — to families, schools, and health care systems, we are hopeful that this line of studies may help meet the need for medications that treat core symptoms.”
http://www.sciencedaily.com/releases/2012/04/120425143634.htm

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism (Abstract)
http://stm.sciencemag.org/content/4/131/131ra51

As Maine heroin overdoses soar, a life-saving drug is within reach
Gideon is sponsoring a bill to give police, volunteer firefighters, drug users and their family members access to Narcan, also known by its generic name naloxone, to administer when someone is in the often-fatal respiratory distress that happens during …
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Heroin epidemic grows in Northern California
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Editorial | Drug addiction is national, not personal, failure
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Question by Mr. Sir: If feminists want equal pay for women?
Then shouldn’t there be pay equity among men first, so it is easier to tell that a woman is getting paid less than all her male colleagues?
@ Jeff- Well men don’t earn the same amount of money as other men. How can we tell that there is true wage disparity between genders if neither gender has a standard wage among themselves?
@ Jiff- Sorry, meant to put Jiff, not Jeff, in the first additional comment.

Best answer:

Answer by Jiffy Ann
well women need the equal
amount of money as men gets

Answer by Empress Luka ルカ
It was “equal pay for equal work,” if you were paying attention.
Just “equal pay period” is Communism.

You don’t need to be a Communist to have equality — just equal opportunity from the starting gate (ensured by taxes to help bring the lower class children to the same starting line. That is: better schools, better health care, etc.) and personal initiative to carry you through, but with some help for those who are physically/mentally handicapped or otherwise disadvantaged.

I am a Liberal and I believe in helping those in need and doing all that you can to aid the larger community. I am not a Communist simply because I recognize that people need some positive reinforcement to keep them going and on track; purely negative reinforcement just creates unrest and misery.

@ The Fall of Man
I can most certainly hold my own.
Like the vast majority liberals, I am from the educated middle class — the level that can both contribute our efforts in the workforce and still afford to help others, as well as realize the importance of doing so, but doesn’t have the degree of greed and selfishness to launch us into the wealthy class.
I am not sure where the conservative idea that “all liberals are stoopid welfare parasites” came from. Most of us are neither rich nor poor. The wealthy/elite, the country/small town bunch, and the rural poor have always tended to gravitate towards conservatism. Liberalism is always strongest in more updated urban areas with lots of educational and working opportunities as well as a thriving middle class.

@ The Fall of Man
So, do you think it fair that people are born into poverty and therefore can’t get a very good education, so that the get lower-paying “un-skilled” jobs and will likely stay poor?
Do you think it fair that because someone is born with a physical/mental disease and disables them from working, they should have to suffer for it?
Eventually, if everything works out the right way, everyone should have an amazing education, complete safety, advanced healthcare, and as much community [moral] support as possible, regardless of what class he/she was born into. Therefore, whether you succeed and fail would become 110% you, not your birth class, not luck, not talent, not your family/parents, not money/resources, etc. Just you. If you hate this idea, it’s probably because you like being lucky and don’t want to have more people to compete with in the workforce — in that case, you are being a petty elitist (thinking that you are by nature better or more deserving than everyone else).
For this to equal starting-ground to be a reality, everyone needs to pitch in. Those with more are just going to have to give a little more. Don’t worry, there’ll still be a hierarchy — just not one dependent on luck and birth, but rather true hard work.
This starts now. If you keep chucking the weight on your descendants, nothing will ever get done. Everyone needs to give some and pledge themselves to the greater good, at least in part, today and every day.

@ The Fall of Man
Fine, I’ll try to make it simple so you can understand me.
I said it before and I can say it again: Liberals do not “steal people’s money.”
We give our aid, surplus derived from OUR OWN sweat and blood, to the disadvantaged and expect others to help as well. Everyone needs to pay their fair share. If I can be a good person and a part of the community, you can too.
I believe in some hierarchy, but hierarchy based off of hard work, determination, and mutual respect — not luck. If, growing up, you had loving parents, received a quality education, lived in a safe area, got medical treatment when you needed it, had no physical/mental disorders, had a roof over your head, weren’t pressured into drugs/alcohol/gangs while you were too young to know those were bad ideas, weren’t abused or bullied, weren’t threatened with violence into intentionally get lower grades, and/or didn’t face prejudice, you were VERY LUCKY. Many many people never got those privileges and, therefore, couldn’t have gotten into the same place you are in now no matter how hard they worked. And sometimes those people need a little extra help.

Alpharetta mom educates community on growing teen drug abuse
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Is Decriminalization the Best Approach to Vermont's, and Nation's, Drug Abuse …
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Cumberland County treatment court addresses the issue of drugs, their effect …
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Two arrested after Anaheim shooting, robbery
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As a Former Marineland Trainer, I Can Tell You That Dolphins Feel
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Expert Orange County Nose Surgeon, Dr. Kevin Sadati, Announces Advantages …
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